have an illness that means you need to control how much salt (sodium) is in your diet, such as high blood pressure or cirrhosis – some antacids contain high levels of sodium, which could make you unwell

Warning. Do not exceed the stateo dose. KltP OUT OF THE SIGHT AND REACH OF CrilLDRtd. Do not store above 25°C. This medicinal product contains 137 mg sodium per capsule, equivalent to approximately 7% of the WHO recommended maximum daily intake of 2 g sodium for an adult. The maximum daily dose of this product (10 capsules) is equivalent to 68% of the WHO recommended maximum daily intake for sodium. This should be particularly taken into account for those on a low salt diet. Discuss your treatment with your doctor before taking this medicine if any of the above applies to you. Alternatives: (TLS Blue) Calcichew ® (calcium carbonate) chewable tablet Calcium 500 ® (calcium carbonate) tablet The manufacturers advise caution if sodium bicarbonate is used when breastfeeding. The effects of sodium administration during breastfeeding are unknown. Side Effects

Adults

In one study, absorption of orally administered sodium hydrogen carbonate in the form of gastro-resistant capsules versus IV administration was studied by measuring the acid-base status and renal Na + elimination. Serum Bicarbonate - L Mc Naughton, D Thompson Acute versus chronic sodium bicarbonate ingestion and anaerobic work and power output J Sports Med Phys Fitness. (2001 Dec)

Manufacturer: Aspar Pharmaceuticals Ltd, 29-30 Capitol Way, Capitol Way Industrial Park, Colindale, EaJi vap.ule contains: sodium bicarbonate 500 mg, which provides 137 mg of sodium. Not recommended for use in children under 12 years,Bo uniess prescribed jy a doctor. Read all the leaflet hefore use. When used before exercise, supplemental dosages of sodium bicarbonate are in the 200–300 mg/kg range. While 200 mg/kg seems to produce an ergogenic effect in most people, 300 mg/kg appears to be the optimal dose. Doses of 400–500 mg/kg are also ergogenic when taken before exercise, but not necessarily more than lower doses. These higher doses also tend to be associated with a higher degree of intestinal side effects.As per NICE guidance TA117 Cinacalcet for the treatment of secondary hyperparathyroidism in patients with end-stage renal disease on maintenance dialysis therapy Insulin - Smellie WS, O'Donnell J, Davidson H, Couper J, Logue FC Effects of changes in acid base and calcium concentration on fasting serum insulin, proinsulin, and glucose concentrations J Clin Pathol. (1994 Nov) Serum Bicarbonate - Costill DL, Verstappen F, Kuipers H, Janssen E, Fink W Acid-base balance during repeated bouts of exercise: influence of HCO3 Int J Sports Med. (1984 Oct)

Power Output - Kupcis PD, Slater GJ, Pruscino CL, Kemp JG Influence of sodium bicarbonate on performance and hydration in lightweight rowing Int J Sports Physiol Perform. (2012 Mar) For long term treatment courses for patients where other preparations are not suitable or tolerated

Calcimimetic agents

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. Sodium bicarbonate (baking soda) is a supplement that provides dietary bicarbonate, which can increase serum levels of bicarbonate (normally produced by the kidneys) and subsequently buffer acid production in the body. The main mechanism of action of sodium bicarbonate is in negating the effects of acidosis. It provides benefits both in situations of chronic mild acidosis, commonly seen in metabolic ailments or during aging as kidney function slowly declines, and in exercise-induced acidosis. The normal concentration range of bicarbonate in plasma is 22 to 32 mmol per litre. The average intake of bicarbonate in the diet is negligible and very little is excreted inthe urine under normal conditions; bicarbonate ions formed in the body are excretedin biliary, intestinal, pancreatic and salivary fluids. If bicarbonate is administeredtherapeutically thus increasing the plasma-bicarbonate concentration above thenormal range then compensatory renal mechanisms come to play and bicarbonate isexcreted in the urine. 5.2 Pharmacokinetic properties For use for management of hyperphosphataemia in dialysis patients with serum phosphate levels that are not controlled after calcium based binder and sevelamer have been tried or in patients intolerant to other agents